Reagents

Biological Reagents

Consumables

Consumables

Instruments

Flow Cytometers

Culture Dishes

Culture Dishes

CD23 MONOCLONAL ANTIBODY

FLUOROCHROMES FITC, PE, PERCP-CY5.5, APC.

CD23 (Fc epsilon RII), the low affinity IgE receptor, is a 45 kDa type II membrane glycoprotein expressed more or less on eosinophils, follicular dendritic cells, Langerhans cells, mature B cells (mainly upon activation), EBV-transformed lymphoblasts, monocytes, and subpopulation of platelets. A soluble form of 37 kDa and other its fragments were also described. CD23 mediates IgE-dependent cytotoxicity by eosinophils and macrophages, and downregulates IgE secretion in response to high levels of IgE, involving release of pro-inflammatory cytokines.

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