Reagents

Biological Reagents

Consumables

Consumables

Instruments

Flow Cytometers

Culture Dishes

Culture Dishes

CD29 MONOCLONAL ANTIBODY
CD29 MONOCLONAL ANTIBODY

FLUOROCHROMES: PACIFIC BLUE, FITC, PE, PERCP, APC, CF-BLUE, OC515.

CD29 (beta1 integrin subunit, GPIIa) forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CD49a-f) determining the binding properties of beta1 (VLA) integrins. These integrins mediate cell adhesion to collagen, fibronectin, laminin and other extracellular matrix (ECM) components. This interaction hinders cell death, whereas disruption of anchorage to ECM leads to apoptosis. Decreased expression of most beta1 integrins correlates with acquiring multidrug resistance of tumour cells during selection in presence of antitumour drug. In platelets, translocation of intracellular pool of beta1 integrins to the plasma membrane following thrombin stimulation. These integrins are also up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue, as well as in regulating tissue damage and disease symptoms related to inflammatory bowel disease. Through a beta1 integrin-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta.

logosm-biog
16 Evripidou street, 56224 Thessaloniki

Thessaloniki office tel:   +30 2310 558 888  
Thessaloniki office fax:  +30 2310 558 888

Thessaloniki office e-mail 1:  This email address is being protected from spambots. You need JavaScript enabled to view it.
Thessaloniki office e-mail 2:  This email address is being protected from spambots. You need JavaScript enabled to view it.

Athens office tel: +30 6956 768 939 
Athens office e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.  

Company location