FLUOROCHROMES: PACIFIC BLUE, FITC, PE, APC, PE-CY5, PERCP, PERCP-CY5.5, AL. FLUOR 700, CF-BLUE.
The monoclonal antibody is directed against the CD33-antigen (belonging to the Ig-supergene family), which is expressed on human myelomonocytic cells. The monoclonal antibody reacts in the bone marrow from myeloblasts up to myelocytes. CD33-antigen is found on CFU-GEMM, CFU-GM, CFU-G, CFU-M and with erythroid CFU-E but not on earlier precursors. The monoclonal antibody does not react with normal human peripheral B-cells, T-cells and platelets. The monoclonal antibody reacts weakly with blast cells in 70% of patients with Acute Myeloid Leukaemia (AML) and in 30% of adult patients with Acute Lymphoblastic Leukaemia (ALL)